כורכומין

6 באוגוסט 2024

Curcumin, a molecule from the Curcuminoids group of molecules,
is present in extracts generated from the Curcuma Longa
(Turmeric) plant.
As a single natural molecule, Curcumin provides perhaps the
broadest array of potential health and wellness benefits known to
science.
Albeit its array of potential benefits, these are not realized today as an outcome of the very
poor bioavailability of Curcumin in in raw extract form (typically: 5 nanogram per each 1 mg.
of raw Curcumin taken).
Vital undertook to develop a high-solubility and resulting high-bioavailability version of
Curcumin. TurmericEBATM (Enhanced Bio Availability) incorporates raw Curcumin extract
with a proprietary mix of food-grade bioavailability-enhancing excipients. This proprietary was
successfully tested side-by-side with the leading commercial Curcumin bioavailability
enhancing products. In this comparison, TurmericEBATM provided the best water-solubility
properties.

Curcumin’s Mechanisms-of-Action
Curcumin impacts a broad array of biological process, enzymes and receptors in the human
body. The key biological properties of Curcumin are:
• COX-2 inhibition
• JAK/STAT inhibition
• NF-kB inhibition
• MOAs inhibition
• PI3K/Akt inhibition
• ERK/BDNF activation
• AMPK activation
• SIRT activation
• Glutathione activation
• P53 activation
A number of these mechanisms-of-action controlled by Curcumin are tightly related to both

the prevention and the treatment of uncontrolled cell growth, key to the development of pre-
cancerous and cancerous tumors.

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